Isavuconazonium, aka Cresemba

Also known as: BAL-8557, UNII-VH2L779W8Q, Isavuconazonium ion, AC1OCFMR, SureCN13133195, CHEMBL1183349 Molecular Formula: C35H35F2N8O5S+ Molecular Weight: 717.764806 g/mol InChI Key: RSWOJTICKMKTER-QXLBVTBOSA-N
Written By:  Pubchem

Date Posted: 2015-01-25

 Neurologic and neuropsychiatric syndrome features of mold and mycotoxin exposure.
Neurologic and neuropsychiatric syndrome features of mold and mycotoxin exposure.

Human exposure to molds, mycotoxins, and water-damaged buildings can cause neurologic and neuropsychiatric signs and symptoms. Many of these clinical features can partly mimic or be similar to classic neurologic disorders including pain syndromes, movement disorders, delirium, dementia, and disorders of balance and coordination. In this article, the author delineates the signs and symptoms of a syndrome precipitated by mold and mycotoxin exposure and contrasts and separates these findings neurodiagnostically from known neurologic diseases. This clinical process is designed to further the scientific exploration of the underlying neuropathophysiologic processes and to promote better understanding of effects of mold/mycotoxin/water-damaged buildings on the human nervous system and diseases of the nervous system. It is clear that mycotoxins can affect sensitive individuals, and possibly accelerate underlying neurologic/pathologic processes, but it is crucial to separate known neurologic and neuropsychiatric disorders from mycotoxin effects in order to study it properly.

Citation: Toxicol Ind Health. 2009 Oct-Nov;25(9-10):577-81. doi: 10.1177/0748233709348393.

1Independent Neurodiagnostic Clinic, Atlanta, GA 30327, USA.

Written By:  Empting LD.

Date Posted: 2009-10-06

 A year after Sandy, mold a lingering problem for buildings, health
One year after Superstorm Sandy, the smell hasn't gone away. Hundreds — possibly thousands — of structures sit in limbo, musty with the stench of mold growing behind padlocked doors. "People are still in limbo," said Tom Peter, the owner of Insurance

One year after Superstorm Sandy, the smell hasn't gone away. Hundreds — possibly thousands — of structures sit in limbo, musty with the stench of mold growing behind padlocked doors. "People are still in limbo," said Tom Peter, the owner of Insurance Restoration Specialists in New Jersey. "There are a lot of houses that haven't been touched." In New York City alone, 433 buildings remain red-tagged as unsafe to enter a year after Sandy blew ashore on Oct. 29, 2012, while 1,013 others are yellow-tagged with some restrictions, according to the Buildings Department. Jeffrey Gross, vice president of operations at Maxons Restorations in New York, said the numbers may be even higher because some people continue to live in their homes if the mold is growing out of sight, such as in basements or behind walls. And that mold can contribute to health problems. He estimated there are a couple of hundred New York City apartment buildings in need of cleanup, and 2,000 to 3,000 single-family homes with mold and other hurricane contamination problems. "Staten Island and Rockaway are probably some of the areas that are furthest behind on the road to recovery," Gross said.
Written By:  Amy Langfield CNBC

Date Posted: 2013-10-29

 Dampness and mould in schools and respiratory symptoms in children: the HITEA study
Alicia Borrŕs-Santos, José H Jacobs, Martin Täubel, Ulla Haverinen-Shaughnessy, Esmeralda JM Krop, Kati Huttunen, Maija-Riitta Hirvonen, Juha Pekkanen, Dick JJ Heederik, Jan-Paul Zock, and Anne Hyvärinen

Background The adverse respiratory health effects of dampness and mould in the home have been extensively reported, but few studies have evaluated the health effects of such exposures in schools. Objectives To assess the associations between dampness and mould in school buildings and respiratory symptoms among 6–12-year-old pupils in three European countries with different climates. Methods Based on information from self-reports and observations, we selected 29 primary schools with and 27 without moisture damage in Spain, the Netherlands and Finland. Information on respiratory symptoms and potential determinants was obtained using a parent-administered questionnaire among 6–12-year-old pupils. Country-specific associations between moisture damage and respiratory symptoms were evaluated using multivariable multilevel mixed effects logistic regression analysis. Results Data from 9271 children were obtained. Nocturnal dry cough was consistently associated with moisture damage at school in each of the three countries: OR 1.15; 95% CI 1.00 to 1.30 with p for heterogeneity 0.54. Finnish children attending a moisture damaged school more often had wheeze (OR 1.36; CI 1.04 to 1.78), nasal symptoms (OR 1.34; CI 1.05 to 1.71) and respiratory-related school absence (OR 1.50; CI 1.10 to 2.03). No associations with these symptoms were found in the Netherlands or Spain (p for heterogeneity <0.05). Conclusions Moisture damage in schools may have adverse respiratory health effects in pupils. Finnish school children seem to be at higher risk, possibly due to quantitative and/or qualitative differences in exposure.
Written By:  Borrŕs-Santos, Jacobs, taubel, shaughnessy, crop, huttunen, Hirvonen

Date Posted: 2013-10-16

 Correlation Between Alt a 1 Levels and Clinical Symptoms in Alternaria alternata– Monosensitized Patients
In patients who are allergic to A alternata, Alt a 1 levels can be considered an important marker for predicting the risk of respiratory symptoms.PMID: 22697004 [PubMed - indexed for MEDLINE] Free full text

Written By:  F Feo Brito,1 AM Alonso,1 J Carnés,2 R Martín-Martín,3 E Fernández-Caldas,2 PA Galindo,1 T Alfaya,1

Date Posted: 2012-06-25


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